DNA Test: lactose + Celiac Disease + Vit. D
News: 3 tests in 1, to do at home in complete comfort.
Specific DNA tests for lactose intolerance, celiac disease and for the correct assimilation of vitamin D.
The genetic tes, or DNA test, consists of a buccal swab or the collection of the oral mucosa to be carried out by crawling the swab, which you will find around the package, under the tongue or inside the cheek.
DNA testing is very simple and fast. Once the withdrawal is made, just communicate the presence of the sample ready to send to the number that you will find in the instructions inside the package and you will be contacted by a courier for the collection of the same.
The report will be sent to you by email within 15 days.
Find out your physical condition and predisposition to intolerance to milk and dairy products. Genetic testing is a valid tool for diagnosing lactose intolerance if accompanied by the typical symptoms of intolerance.
The test allows to discriminate the C/T polymorphism at position 13910, i.e. if in the lactase gene (LCT), in chromosome 2, the copies of the gene are healthy (genotype T/T -> no intolerance), if it has undergone a mutation (genotype T/C -> no intolerance) or if it has undergone both mutations (genotype C/C, homozygosis -> lactose intolerance).
Features of Lactosolution lactose intolerance genetic test:
- - Possibility to do it at home, when you are more comfortable and at the time you want
- - High sensitivity (97%) i.e. very low probability of false negatives
- - High specificity (95%) i.e. low probability of false positives
- - Quick and easy to perform, also suitable for children and babies
- - Non-invasive
- - Does not cause disturbances
- - Complementary to the Breath test C13 or the Breath Test H2
Celiac disease, or autoimmune gluten enteropathy, is a permanent intolerance to gluten contained in wheat, barley, spelled, rye and oat flours. Genetic testing allows the diagnosis of celiac disease.
The main genetic risk factors are specific haplotypes (allelic combinations) of HLA class II genes of the major histocompatibility complex (HLA-DQ2 and HLA-DQ8). DQ2 and DQ8 are glycoproteins, formed by two chains (Alpha and beta) encoded by the DQA1 and dqb1 genes, respectively. The DQA1*05 and DQB1*02 alleles encode for DQ2 at higher risk of celiac disease, while the DQA1*03 and DQB1*03:02 alleles for DQ8 at lower risk of celiac disease.
Vitamin D plays important biological functions in our body, promotes intestinal and renal absorption of calcium and is essential for the development and maintenance of bone mass. Discover your individual ability to assimilate and use vitamin D contained in food, influencing the biological processes controlled by it.
For vitamin D, the vitamin D receptor (VDR) is investigated, which is involved in homeostasis and calcium absorption and is implicated in bone mineralization. The Taqi polymorphism of the VDR gene, localized in exon 9, consists of a T/C nucleotide variation at the -352 position. The mutation compromises the metabolism of vitamin D and leads to an increase in bone cell turnover with a consequent increase in the risk of osteoporosis especially in subjects with C/C genotype.
The correct collection of the oral mucosa sample requires cleaning the oral cavity (brush your teeth or rinse your mouth a few minutes first) to avoid food residues that may remain adherent to the swab.
The test can also be carried out on newborns.
More information about the genetic Test for lactose intolerance can be found in the following article of our BLOG: click here